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Molecular Biology and Genetics Unit (MBGU)

Molecular Biology and Genetics Unit (MBGU)

 

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  • Mitra, Anirban; Misquitta, Rachel; Nagaraja, V. (Public Library of Science, 2014)
    Two mechanisms - factor independent and dependent termination - ensure the completion of RNA synthesis in eubacteria. Factor-dependent mechanism relies on the Rho protein to terminate transcription by interacting with RNA ...
  • Kumar, Rupesh; Madhumathi, Bhavani Shankar; Nagaraja, V. (American Society Microbiology, 2014)
    DNA gyrase is a type II topoisomerase that catalyzes the introduction of negative supercoils in the genomes of eubacteria. Fluoroquinolones (FQs), successful as drugs clinically, target the enzyme to trap the gyrase-DNA ...
  • Ahmed, Wareed; Menon, Shruti; Godbole, Adwait Anand; Karthik, Pullela V. D. N. B.; Nagaraja, V. (Oxford University Press, 2014)
    Topoisomerases are an important class of enzymes for regulating the DNA transaction processes. Mycobacterium tuberculosis (Mtb) is one of the most formidable pathogens also posing serious challenges for therapeutic ...
  • Ghosh, Soumitra; Mallick, Bratati; Nagaraja, V. (Oxford University Press, 2014)
    The topological homeostasis of bacterial chromosomes is maintained by the balance between compaction and the topological organization of genomes. Two classes of proteins play major roles in chromosome organization: the ...
  • Kundu, Partha P.; Bhowmick, Tuhin; Swapna, Ganduri; Kumar, G. V. Pavan; Nagaraja, V.; Narayana, Chandrabhas (American Chemical Society, 2014)
    We demonstrate the utility of the surface-enhanced Raman spectroscopy (SERS) to monitor conformational transitions in protein upon ligand binding. The changes in protein's secondary and tertiary structures were monitored ...
  • Bhowmick, Tuhin; Ghosh, Soumitra; Dixit, Karuna; Ganesan, Varsha; Ramagopal, Udupi A.; Dey, Debayan; Sarma, Siddhartha P.; Ramakumar, Suryanarayanarao; Nagaraja, V. (Nature Publishing Group, 2014)
    The nucleoid-associated protein HU plays an important role in maintenance of chromosomal architecture and in global regulation of DNA transactions in bacteria. Although HU is essential for growth in Mycobacterium tuberculosis ...
  • Godbole, Adwait Anand; Ahmed, Wareed; Bhat, Rajeshwari Subray; Bradley, Erin K.; Ekins, Sean; Nagaraja, V. (Academic Press Inc Elsevier Science, 2014)
    m-AMSA, an established inhibitor of eukaryotic type II topoisomerases, exerts its cidal effect by binding to the enzyme-DNA complex thus inhibiting the DNA religation step. The molecule and its analogues have been successfully ...
  • Rajasekhar, Kolla; Narayanaswamy, Nagarjun; Mishra, Piyush; Suresh, S. N.; Manjithaya, Ravi; Govindaraju, T. (Wiley-V C H Verlag Gmbh, 2014)
    Cyclic peptoids are potential candidates for diverse biological activities. However, applications of cyclic peptoids are limited by the synthetic difficulties, conformational flexibility of large cyclic peptoids, and lack ...
  • Maity, Debabrata; Raj, Anand; Samanta, Pralok K.; Karthigeyan, D.; Kundu, Tapas Kumar; Pati, Swapan Kumar; Govindaraju, T. (Royal Society of Chemistry, 2014)
    A ratiometric, near-infrared (NIR), fluorescence and colorimetric probe DNPOCy for hydrogen sulfide (H2S) has been developed. The chemical basis for the operation of the probe is thiolysis of a dinitrophenyl ether, which ...
  • Prabhakaran, Priya M.; Sheeba, Vasu (Informa Healthcare, 2014)
    Light and temperature are the major environmental cycles that can synchronize circadian rhythms in a variety of organisms. Previously, we have shown that under light/dark cycles of various photoperiods, the Drosophila ...
  • Prabhakaran, Priya M.; Sheeba, Vasu (Springer, 2014)
    Recent studies under semi-natural conditions have revealed various unique features of activity/rest rhythms in Drosophilids that differ from those under standard laboratory conditions. An additional afternoon peak (A-peak) ...
  • Jose, Diego Pandelo; Bartholomeeusen, Koen; da Cunha, Rodrigo Delvecchio; Abreu, Celina Monteiro; Glinski, Jan; Ferreira da Costa, Thais Barbizan; Mello Bacchi Rabay, Ana Flavia; Pianowski Filho, Luiz Francisco; Dudycz, Lech W.; Ranga, Udaykumar; Peterlin, Boris Matija; Pianowski, Luiz Francisco; Tanuri, Amilcar; Aguiar, Renato Santana (Academic Press Inc Elsevier Science, 2014)
    The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent ...
  • Kashi, Venkatesh P.; Jacob, Rajesh A.; Shamanna, Raghavendra A.; Menon, Malini; Balasiddaiah, Anangi; Varghese, Rebu K.; Bachu, Mahesh; Ranga, Udaykumar (Public Library of Science, 2014)
    Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity ...
  • Ramana, Lakshmi Narashimhan; Sharma, Shilpee; Sethuraman, Swaminathan; Ranga, Udaykumar; Krishnan, Uma Maheswari (Elsevier Science Bv, 2014)
    Background: Antiretroviral Therapy (ART) is currently the major therapeutic intervention in the treatment of AIDS. ART, however, is severely limited due to poor availability, high cytotoxicity, and enhanced metabolism and ...
  • Boullosa, Jose; Bachu, Mahesh; Bila, Dulce; Ranga, Udaykumar; Sueffert, Theodoro; Sasazawa, Tomoko; Tanuri, Amilcar (Mdpi Ag, 2014)
    The HIV-1 subtype C has been substituting the subtype B population in southern Brazil. This phenomenon has been previously described in other countries, suggesting that subtype C may possess greater fitness than other ...
  • Verma, Garima; Surolia, Namita (Biomed Central Ltd, 2014)
    Background: The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. ...
  • Khadilkar, Rohan J.; Rodrigues, Diana; Mote, Ridim Dadasaheb; Sinha, Arghyashree Roychowdhury; Kulkarni, Vani; Magadi, Srivathsa Subramanya; Inamdar, Maneesha S. (National Academy of Sciences, 2014)
    Drosophila melanogaster larval hematopoiesis is a well-established model to study mechanisms that regulate hematopoietic niche maintenance and control of blood cell precursor (prohemocyte) differentiation. Molecules that ...
  • Mitra, Sreyoshi; Gomez-Raja, Jonathan; Larriba, German; Dubey, Dharani Dhar; Sanyal, Kaustuv (Public Library of Science, 2014)
    Specification of the centromere location in most eukaryotes is not solely dependent on the DNA sequence. However, the non-genetic determinants of centromere identity are not clearly defined. While multiple mechanisms, ...
  • Janbon, Guilhem; Ormerod, Kate L.; Paulet, Damien; Byrnes, Edmond J., III; Yadav, Vikas; Chatterjee, Gautam; Mullapudi, Nandita; Hon, Chung-Chau; Billmyre, R. Blake; Brunel, Francois; Bahn, Yong-Sun; Chen, Weidong; Chen, Yuan; Chow, Eve W. L.; Coppee, Jean-Yves; Floyd-Averette, Anna; Gaillardin, Claude; Gerik, Kimberly J.; Goldberg, Jonathan; Gonzalez-Hilarion, Sara; Gujja, Sharvari; Hamlin, Joyce L.; Hsueh, Yen-Ping; Ianiri, Giuseppe; Jones, Steven; Kodira, Chinnappa D.; Kozubowski, Lukasz; Lam, Woei; Marra, Marco; Mesner, Larry D.; Mieczkowski, Piotr A.; Moyrand, Frederique; Nielsen, Kirsten; Proux, Caroline; Rossignol, Tristan; Schein, Jacqueline E.; Sun, Sheng; Wollschlaeger, Carolin; Wood, Ian A.; Zeng, Qiandong; Neuveglise, Cecile; Newlon, Carol S.; Perfect, John R.; Lodge, Jennifer K.; Idnurm, Alexander; Stajich, Jason E.; Kronstad, James W.; Sanyal, Kaustuv; Heitman, Joseph; Fraser, James A.; Cuomo, Christina A.; Dietrich, Fred S. (Public Library of Science, 2014)
    Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ...
  • Srinivasan, Bharath; Forouhar, Farhad; Shukla, Arpit; Sampangi, Chethana; Kulkarni, Sonia; Abashidze, Mariam; Seetharaman, Jayaraman; Lew, Scott; Mao, Lei; Acton, Thomas B.; Xiao, Rong; Everett, John K.; Montelione, Gaetano T.; Tong, Liang; Balaram, Hemalatha (Wiley-Blackwell, 2014)
    Cytosolic nucleotidase II (cN-II) from Legionellapneumophila (Lp) catalyzes the hydrolysis of GMP and dGMP displaying sigmoidal curves, whereas catalysis of IMP hydrolysis displayed a biphasic curve in the initial rate ...

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