Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/581
Title: The Relationship between Delta-Aminolaevulinate Synthetase Induction and the Concentrations of Cytochrome P-450 and Catalase in Rat Liver
Authors: Rao, M R S
Malathi, K
Padmanaban, G
Keywords: 5-Aminolevulinate Synthetase - biosynthesis
Amides - pharmacology
Animals
Bilirubin - pharmacology
Catalase - biosynthesis
Cycloheximide - pharmacology
Cytochrome P-450 Enzyme System - biosynthesis
Enzyme Induction
Female
Glucose - pharmacology
Half-Life
Heme - pharmacology
Liver - enzymology
Microsomes
Liver - metabolism
Phenobarbital - pharmacology
Porphyrins - metabolism
Proadifen - pharmacology
Rats
Issue Date: 1972
Publisher: The Biochemical Society
Citation: Biochemical Journal 127(3), 553-559 (1972)
Abstract: The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of δ-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of δ-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the `derepression' of δ-aminolaevulinate synthetase.
Description: Restricted Access
URI: http://hdl.handle.net/10572/581
Other Identifiers: 0264-6021
Appears in Collections:Research Papers (M.R.S. Rao)

Files in This Item:
File Description SizeFormat 
sl.no.4.(1972)Biochem. J. 127, 553-559.pdf
  Restricted Access
1.07 MBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.