Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/487
Title: Molecular features of meiotic recombination hot spots
Authors: Nishant, K T
Rao, M R S
Keywords: Double-Strand Breaks
Major Histocompatibility Complex
Class-Ii Region
High-Resolution Analysis
Saccharomyces-Cerevisiae
Linkage-Disequilibrium
Gene Conversion
Human Genome
Initiation Site
Crossing-Over
Issue Date: Jan-2006
Publisher: John Wiley & Sons Inc
Citation: BioEssays 28(1), 45–56 (2006)
Abstract: Meiotic recombination occurs preferentially at certain regions called hot spots and is important for generating genetic diversity and proper segregation of chromosomes during meiosis. Hot spots have been characterized most extensively in yeast, mice and humans. The development of methods based on sperm typing and population genetics has facilitated rapid and high-resolution mapping of hot spots in mice and humans in recent years. With increasing information becoming available on meiotic recombination in different species, it is now possible to compare several molecular features associated with hot-spot loci. Further, there have been advances in our knowledge of the factors influencing hot-spot activity and the role that they play in structuring the genome into haplotype blocks. We review the molecular features associated with hot spots in terms of their properties and mechanisms underlying their function and distribution. A large number of these features seem to be shared among hot spots from different species suggesting common mechanisms for their formation and function.
Description: Restricted Access
URI: http://hdl.handle.net/10572/487
Other Identifiers: 0265-9247
Appears in Collections:Research Papers (M.R.S. Rao)

Files in This Item:
File Description SizeFormat 
sl.no.105.2006 BioEssays 28,45-56.pdf
  Restricted Access
322.55 kBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.