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Title: Nmp3 A Member Of The Nucleophosmin/Nucleoplasmin Family, Enhances Activator Dependent Transcription
Authors: Gadad, Shrikanth S
Shandilya, Jayasha
Kishore, A Hari
Kundu, Tapas K
Keywords: Protein
Issue Date: 23-Feb-2010
Publisher: American Chemical Society
Citation: BioChemistry 49(7), 1355-1357 (2010)
Abstract: The chromatin is comprised of repeating subunits that make up the nucleosome which is composed of an octamer of histories: H3, H4, H2A, and H2B. The replication-dependent and -independent nucleosome assembly occurs in an ordered fashion and is aided by cellular proteins such as historic chaperones and chromatin remodelers. Previously, we found that the histone chaperone NPM1 activates transcription from the chromatin template. Here we report that NPM3, a member of the nucleophosmin/nucleoplasmin family, lacks intrinsic histone chaperone activity, inhibits historic assembly activity of NPM1 in vitro, and dramatically enhances transcription in a cellular system.
Description: Restricted Access
Other Identifiers: 0006-2960
Appears in Collections:Research Papers (Tapas K. Kundu)

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