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Title: Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects
Authors: Radha, V
Vimaleswaran, Karani S
Babu, H N S
Abate, Nicola
Chandalia, Manisha
Satija, Pankaj
Grundy, Scott M
Ghosh, Saurabh
Majumder, Partha P
Deepa, Raj
Rao, M R S
Mohan, Viswanathan
Keywords: Proliferator-Activated Receptor-Gamma-2
Insulin Sensitivity
High Prevalence
Issue Date: May-2006
Publisher: American Diabetes Association
Citation: Diabetes Care 29(5), 1046-1051 (2006)
Abstract: OBJECTIVE - To determine whether the peroxisome proliferator-activated receptor (PPAR)-gamma Pro12ala polymorphism modulates susceptibility to diabetes in South Asians. RESEARCH DESIGN AND METHODS - South Asians (n = 697) and Caucasians (n = 457) living in Dallas/Forth Worth, Texas, and South Asians living in Chennai, India (n = 1,619), were enrolled for this study. PPAR-gamma Pro12Ala was determined using restriction fragment-length polymorphism. Insulin responsiveness to an oral glucose tolerance test (OGTT) was measured in nondiabetic subjects. RESULTS - The Caucasian diabetic subjects had significantly lower prevalence of PPAR-gamma 12Ala when compared with the Caucasian nondiabetic subjects (20 vs. 9%, P = 0.006). However, there were no significant differences between diabetic and nondiabetic subjects with reference to the Pro12Ala polymorphism among the South Asians living in Dallas (20 vs. 23%) and in India (19 vs. 19.3%). Although Caucasians carrying PPAR-gamma Pro12Ala had lower plasma insulin levels at 2 h of OGTT than the wild-type (Pro/Pro) carriers (76 +/- 68 and 54 +/- 33 mu U/ml, respectively, P = 0.01), no differences in either fasting or 2-h plasma insulin concentrations were found between South Asians carrying the PPAR-gamma Pro12Ala polymorphism and those with the wild-type genotype at either Chennai or Dallas. CONCLUSIONS - Although further replication studies are necessary to test the validity of the described genotype-phenotype relationship, our study supports the hypothesis that the PPAR-gamma Pro12Ala polymorphism is protective against diabetes in Caucasians but not in South Asians.
Description: Restricted Access
Other Identifiers: 0149-5992
Appears in Collections:Research Papers (M.R.S. Rao)

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