Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/2533
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dc.contributor.authorCharlesworth, Brian
dc.contributor.authorJain, Kavita
dc.date.accessioned2017-02-21T09:01:00Z-
dc.date.available2017-02-21T09:01:00Z-
dc.date.issued2014
dc.identifier.citationCharlesworth, B; Jain, K, Purifying Selection, Drift, and Reversible Mutation with Arbitrarily High Mutation Rates. Genetics 2014, 198 (4) 1587-+, http://dx.doi.org/10.1534/genetics.114.167973en_US
dc.identifier.citationGeneticsen_US
dc.identifier.citation198en_US
dc.identifier.citation4en_US
dc.identifier.issn0016-6731
dc.identifier.urihttp://hdl.handle.net/10572/2533-
dc.descriptionRestricted Accessen_US
dc.description.abstractSome species exhibit very high levels of DNA sequence variability; there is also evidence for the existence of heritable epigenetic variants that experience state changes at a much higher rate than sequence variants. In both cases, the resulting high diversity levels within a population (hyperdiversity) mean that standard population genetics methods are not trustworthy. We analyze a population genetics model that incorporates purifying selection, reversible mutations, and genetic drift, assuming a stationary population size. We derive analytical results for both population parameters and sample statistics and discuss their implications for studies of natural genetic and epigenetic variation. In particular, we find that (1) many more intermediate-frequency variants are expected than under standard models, even with moderately strong purifying selection, and (2) rates of evolution under purifying selection may be close to, or even exceed, neutral rates. These findings are related to empirical studies of sequence and epigenetic variation.en_US
dc.description.uri1943-2631en_US
dc.description.urihttp://dx.doi.org/10.1534/genetics.114.167973en_US
dc.language.isoEnglishen_US
dc.publisherGenetics Society Americanicaen_US
dc.rights@Genetics Society Americanica, 2014en_US
dc.subjectGenetics & Heredityen_US
dc.subjectSynonymous Codon Usageen_US
dc.subjectMolecular Hyperdiversityen_US
dc.subjectEpigenetic Variationen_US
dc.subjectFrequency-Spectrumen_US
dc.subjectDNA Polymorphismen_US
dc.subjectArabidopsis-Thalianaen_US
dc.subjectFinite Populationsen_US
dc.subjectSegregating Sitesen_US
dc.subjectEvolutionen_US
dc.subjectPatternsen_US
dc.titlePurifying Selection, Drift, and Reversible Mutation with Arbitrarily High Mutation Ratesen_US
dc.typeArticleen_US
Appears in Collections:Research Articles (Kavita Jain)

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