Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/2490
Title: Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles
Authors: Kumar, S. Vijay
Saraiah, B.
Parameshwarappa, G.
Ila, H.
Verma, Girijesh K.
Keywords: Organic Chemistry
H-Bond Functionalizations
2,3-Disubstituted Indoles
Efficient Synthesis
Regioselective Synthesis
Cross-Couplings
Methylene Isocyanides
2-Substituted Indoles
Oxidative Cyclization
Versatile Template
Modular Synthesis
Issue Date: 2014
Publisher: American Chemical Society
Citation: Kumar, SV; Saraiah, B; Parameshwarappa, G; Ila, H; Verma, GK, Synthesis of N-Functionalized/NH-Multisubstituted Indoles, Thienopyrroles, Pyrroloindoles, and Pyrazolopyrroles via Sequential One-Pot Base-Mediated and Copper-Catalyzed Inter- and Intramolecular Amination of 2-[2-Bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitriles. Journal of Organic Chemistry 2014, 79 (17) 7961-7978, http://dx.doi.org/10.1021/jo501114a
Journal of Organic Chemistry
79
17
Abstract: A novel, efficient route to substituted 1-N-(het)aryl/NH-2-(het)aryl-3-cyanoindoles and related pyrrolo-fused heterocycles such as thienopyrroles, pyrroloindoles, and pyrazolopyrroles has been reported. The overall protocol involves sequential cycloamination of readily available 2-[2-bromo(het)aryl]-3-(het)aryl-3-(methylthio)acrylonitrile precursors with primary amines or amides via two key C-N bond-forming processes, one base-mediated intermolecular and the other Cu-catalyzed intramolecular arylamination leading to N(1)-C(2) and N(1)-C(7a) bond formation, respectively, in a two-step one-pot procedure.
Description: Restricted Access
URI: http://hdl.handle.net/10572/2490
Appears in Collections:Research Papers (H. Ila)

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