Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/242
Title: p53 regulates its own activator: transcriptional co-activator PC4, a new p53-responsive gene
Authors: Kishore, A Hari
Batta, Kiran
Das, Chandrima
Agarwal, Shipra
Kundu, Tapas K
Keywords: chromatin immunoprecipitation
DNA damage
p53
PC4
promoter
transcription
DNA-Binding
Protein
Target
Damage
Transactivation
Acetylation
Cofactor
Mediator
Ligase
Sites
Issue Date: 15-Sep-2007
Publisher: Biochemical Society(PortLand Press Ltd)
Citation: Biochemical Journal 406(3), 437-444 (2007)
Abstract: The tumour suppressor protein p53 regulates the expression of several genes that mediate cell cycle arrest, apoptosis, DNA repair and other cellular responses. Recently, we have shown that human transcriptional co-activator PC4 is a unique activator of p53 function. In the present study, we report that PC4 is a p53-inducible gene. Bioinformatics analysis reveals multiple p53-binding sites in the PC4 promoter. We have found that indeed p53 binds to all the identified sites in vitro and in vivo with varying affinities. p53 acts as an activator of PC4 transcription. Both PC4 mRNA and protein levels increase in response to stimuli that result in p53 induction. Furthermore, PC4 enhances p53 recruitment to the PC4 promoter. Our results thus establish the first report of a positively regulated feedback loop to control p53 function.
URI: http://hdl.handle.net/10572/242
Other Identifiers: 0264-6021
Appears in Collections:Research Papers (Tapas K. Kundu)

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