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dc.contributor.authorDas, Antara
dc.contributor.authorHolmes, Todd C.
dc.contributor.authorVasu, Sheeba
dc.date.accessioned2017-01-24T06:53:33Z-
dc.date.available2017-01-24T06:53:33Z-
dc.date.issued2016
dc.identifier.citationDas, A.; Holmes, T. C.; Sheeba, V., dTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogaster. Journal of Biological Rhythms 2016, 31 (3), 272-288 http://dx.doi.org/10.1177/0748730415627037en_US
dc.identifier.citationJournal of Biological Rhythmsen_US
dc.identifier.citation31en_US
dc.identifier.citation3en_US
dc.identifier.issn0748-7304
dc.identifier.urihttp://hdl.handle.net/10572/2291-
dc.descriptionRestricted Accessen_US
dc.description.abstractIn fruit flies Drosophila melanogaster, environmental cycles of light and temperature are known to influence behavioral rhythms through dedicated sensory receptors. But the thermosensory pathways and molecular receptors by which thermal cycles modulate locomotor activity rhythms remain unclear. Here, we report that neurons expressing warmth-activated ion channel Drosophila Transient Receptor Potential-A1 (dTRPA1) modulate distinct aspects of the rhythmic activity/rest rhythm in a light-dependent manner. Under light/dark (LD) cycles paired with constantly warm ambient conditions, flies deficient in dTRPA1 expression are unable to phase morning and evening activity bouts appropriately. Correspondingly, we show that electrical activity of a few neurons targeted by the dTRPA1(SH)-GAL4 driver modulates temperature-dependent phasing of activity/rest rhythm under LD cycles. The expression of dTRPA1 also affects behavior responses to temperature cycles combined with constant dark (DD) or light (LL) conditions. We demonstrate that the mid-day "siesta" exhibited by flies under temperature cycles in DD is dependent on dTRPA1 expression in a small number of neurons that include thermosensory anterior cell neurons. Although a small subset of circadian pacemaker neurons may express dTRPA1, we show that CRY-negative dTRPA1(SH)-GAL4 driven neurons are critical for the suppression of mid-thermophase activity, thus enabling flies to exhibit siesta. In contrast to temperature cycles in DD, under LL, dTRPA1 is not required for exhibiting siesta but is important for phasing of evening peak. Our studies show that activity/rest rhythms are modulated in a temperature-dependent manner via signals from dTRPA1(SH)-GAL4 driven neurons. Taken together, these results emphasize the differential influence of thermoreceptors on rhythmic behavior in fruit flies in coordination with light inputs.en_US
dc.description.uri1552-4531en_US
dc.description.urihttp://dx.doi.org/10.1177/0748730415627037en_US
dc.language.isoEnglishen_US
dc.publisherSage Publications Incen_US
dc.rights@Sage Publications Inc, 2016en_US
dc.subjectLife Sciences & Biomedicine - Other Topicsen_US
dc.subjectPhysiologyen_US
dc.subjectTRPen_US
dc.subjectcircadianen_US
dc.subjectthermosensationen_US
dc.subjectsiestaen_US
dc.subjectsynchronizationen_US
dc.subjectentrainmenten_US
dc.subjectPacemaker Neuronsen_US
dc.subjectClock Neuronsen_US
dc.subjectLateral Neuronsen_US
dc.subjectBrainen_US
dc.subjectEntrainmenten_US
dc.subjectLighten_US
dc.subjectSynchronizationen_US
dc.subjectPreferenceen_US
dc.subjectChannelsen_US
dc.subjectBehavioren_US
dc.titledTRPA1 in Non-circadian Neurons Modulates Temperature-dependent Rhythmic Activity in Drosophila melanogasteren_US
dc.typeArticleen_US
Appears in Collections:Research Papers (Sheeba Vasu)

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