Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRichard, John Lalith Charles
dc.contributor.authorShukla, Manu Shubhdarshan
dc.contributor.authorMenoni, Herve
dc.contributor.authorOuararhni, Khalid
dc.contributor.authorLone, Imtiaz Nisar
dc.contributor.authorRoulland, Yohan
dc.contributor.authorPapin, Christophe
dc.contributor.authorBen Simon, Elsa
dc.contributor.authorKundu, Tapas Kumar
dc.contributor.authorHamiche, Ali
dc.contributor.authorAngelov, Dimitar
dc.contributor.authorDimitrov, Stefan
dc.identifier.citationRichard, J. L. C.; Shukla, M. S.; Menoni, H.; Ouararhni, K.; Lone, I. N.; Roulland, Y.; Papin, C.; Ben Simon, E.; Kundu, T.; Hamiche, A.; Angelov, D.; Dimitrov, S., FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. Plos Genetics 2016, 12 (7), 21
dc.identifier.citationPLoS Geneticsen_US
dc.descriptionOpen Accessen_US
dc.description.abstractFACT, in addition to its role in transcription, is likely implicated in both transcription-coupled nucleotide excision repair and DNA double strand break repair. Here, we present evidence that FACT could be directly involved in Base Excision Repair and elucidate the chromatin remodeling mechanisms of FACT during BER. We found that, upon oxidative stress, FACT is released from transcription related protein complexes to get associated with repair proteins and chromatin remodelers from the SWI/SNF family. We also showed the rapid recruitment of FACT to the site of damage, coincident with the glycosylase OGG1, upon the local generation of oxidized DNA. Interestingly, FACT facilitates uracil-DNA glycosylase in the removal of uracil from nucleosomal DNA thanks to an enhancement in the remodeling activity of RSC. This discloses a novel property of FACT wherein it has a co-remodeling activity and strongly enhances the remodeling capacity of the chromatin remodelers. Altogether, our data suggest that FACT may acts in concert with RSC to facilitate excision of DNA lesions during the initial step of BER.en_US
dc.publisherPublic Library of Scienceen_US
dc.rights@Public Library of Science, 2016en_US
dc.subjectGenetics & Heredityen_US
dc.subjectNucleosome Core Particleen_US
dc.subjectHistone Octameren_US
dc.subjectH2A-H2B Displacementen_US
dc.subjectChaperone Facten_US
dc.titleFACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSCen_US
Appears in Collections:Research Papers (Tapas K. Kundu)

Files in This Item:
File Description SizeFormat 
205-OA.pdf5.29 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.