Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/2034
Title: Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations
Authors: John, Sona
Jain, Kavita
Keywords: Biology
Mathematical & Computational Biology
Back mutations
Linkage
Finite population
Synonymous Codon Usage
Mullers Ratchet
Asexual Populations
Drosophila-Melanogaster
Beneficial Mutations
Molecular Evolution
Fitness Landscape
Natural-Selection
Speed
Degeneration
Issue Date: 2015
Publisher: Academic Press Ltd- Elsevier Science Ltd
Citation: Journal of Theoretical Biology
365
John, S.; Jain, K., Effect of drift, selection and recombination on the equilibrium frequency of deleterious mutations. J. Theor. Biol. 2015, 365, 238-246.
Abstract: We study the stationary state of a population evolving under the action of random genetic drift, selection and recombination in which both deleterious and reverse beneficial mutations can occur. We find that the equilibrium fraction of deleterious mutations decreases as the population size is increased. We calculate exactly the steady state frequency in a nonrecombining population when population size is infinite and for a neutral finite population, and obtain bounds on the fraction of deleterious mutations. We also find that for small and very large populations, the number of deleterious mutations depends weakly on recombination, but for moderately large populations, recombination alleviates the effect of deleterious mutations. An analytical argument shows that recombination decreases disadvantageous mutations appreciably when beneficial mutations are rare as is the case in adapting microbial populations, whereas it has a moderate effect on codon bias where the mutation rates between the preferred and unpreferred codons are comparable. (C) 2014 Elsevier Ltd. All rights reserved.
Description: Restricted access
URI: http://hdl.handle.net/10572/2034
ISSN: 0022-5193
Appears in Collections:Research Articles (Kavita Jain)

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