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Title: Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection
Authors: Ghosh, Chandradhish
Manjunath, Goutham B.
Konai, Mohini M.
Uppu, Divakara S. S. M.
Hoque, Jiaul
Paramanandham, Krishnamoorthy
Shome, Bibek R.
Haldar, Jayanta
Keywords: Resistant Staphylococcus-Aureus
Combat Bacterial-Resistance
Antimicrobial Peptides
Antibacterial Activity
Small Molecules
Eradicate Biofilms
Barrier Function
Issue Date: 2015
Publisher: Public Library Science
Citation: PLoS One
Ghosh, C.; Manjunath, G. B.; Konai, M. M.; Uppu, D.; Hoque, J.; Paramanandham, K.; Shome, B. R.; Haldar, J., Aryl-Alkyl-Lysines: Agents That Kill Planktonic Cells, Persister Cells, Biofilms of MRSA and Protect Mice from Skin-Infection. PLoS One 2015, 10 (12), 19.
Abstract: Development of synthetic strategies to combat Staphylococcal infections, especially those caused by methicillin resistant Staphyloccus aureus (MRSA), needs immediate attention. In this manuscript we report the ability of aryl-alkyl-lysines, simple membrane active small molecules, to treat infections caused by planktonic cells, persister cells and biofilms of MRSA. A representative compound, NCK-10, did not induce development of resistance in planktonic cells in multiple passages and retained activity in varying environments of pH and salinity. At low concentrations the compound was able to depolarize and permeabilize the membranes of S. aureus persister cells rapidly. Treatment with the compound not only eradicated pre-formed MRSA biofilms, but also brought down viable counts in bacterial biofilms. In a murine model of MRSA skin infection, the compound was more effective than fusidic acid in bringing down the bacterial burden. Overall, this class of molecules bears potential as antibacterial agents against skin-infections.
Description: Restricted access
ISSN: 1932-6203
Appears in Collections:Research Papers (Jayanta Haldar)

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