Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/2001
Title: Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties
Authors: Avinash, M. B.
Raut, Devaraj
Mishra, Manish Kumar
Ramamurty, Upadrasta
Govindaraju, T.
Keywords: Molecular-Crystals
Nanoindentation
Strength
Design
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Scientific Reports
5
Avinash, M. B.; Raut, D.; Mishra, M. K.; Ramamurty, U.; Govindaraju, T., Bioinspired Reductionistic Peptide Engineering for Exceptional Mechanical Properties. Scientific Reports 2015, 5, 8.
Abstract: A simple solution-processing and self-assembly approach that exploits the synergistic interactions between multiple hydrogen bonded networks and aromatic interactions was utilized to synthesize molecular crystals of cyclic dipeptides (CDPs), whose molecular weights (similar to 0.2 kDa) are nearly three orders of magnitude smaller than that of natural structural proteins (50-300 kDa). Mechanical properties of these materials, measured using the nanoindentation technique, indicate that the stiffness and strength are comparable and sometimes better than those of natural fibres. The measured mechanical responses were rationalized by recourse to the crystallographic structural analysis and intermolecular interactions in the self-assembled single crystals. With this work we highlight the significance of developing small molecule based bioinspired design strategies to emulate biomechanical properties. A particular advantage of the successfully demonstrated reductionistic strategy of the present work is its amenability for realistic industrial scale manufacturing of designer biomaterials with desired mechanical properties.
Description: Restricted access
URI: http://hdl.handle.net/10572/2001
ISSN: 2045-2322
Appears in Collections:Research Papers (Govindaraju, T.)

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