Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHoque, Jiaul
dc.contributor.authorAkkapeddi, Padma
dc.contributor.authorYadav, Vikas
dc.contributor.authorManjunath, Goutham B.
dc.contributor.authorUppu, Divakara S. S. M.
dc.contributor.authorKonai, Mohini M.
dc.contributor.authorYarlagadda, Venkateswarlu
dc.contributor.authorSanyal, Kaustuv
dc.contributor.authorHaldar, Jayanta
dc.identifier.citationACS Applied Materials & Interfacesen_US
dc.identifier.citationHoque, J.; Akkapeddi, P.; Yadav, V.; Manjunath, G. B.; Uppu, D.; Konai, M. M.; Yarlagadda, V.; Sanyal, K.; Haldar, J., Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure-Activity Relationship, and Membrane-Active Mode of Action. ACS Applied Materials & Interfaces 2015, 7 (3), 1804-1815.en_US
dc.descriptionRestricted accessen_US
dc.description.abstractMicrobial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections. Noncovalent immobilization of water insoluble and organo-soluble cationic polymers onto a surface is a facile approach to prevent microbial contamination. In the present study, we described the synthesis of water insoluble and organo-soluble polymeric materials and demonstrated their structure-activity relationship against various human pathogenic bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and beta lactam-resistant Klebsiella pneumoniae as well as pathogenic fungi such as Candida spp. and Cryptococcus spp. The polymer coated surfaces completely inactivated both bacteria and fungi upon contact (5 log reduction with respect to control). Linear polymers were more active and found to have a higher killing rate than the branched polymers. The polymer coated surfaces also exhibited significant activity in various complex mammalian fluids such as serum, plasma, and blood and showed negligible hemolysis at an amount much higher than minimum inhibitory amounts (MIAs). These polymers were found to have excellent compatibility with other medically relevant polymers (polylactic acid, PLA) and commercial paint. The cationic hydrophobic polymer coatings disrupted the lipid membrane of both bacteria and fungi and thus showed a membrane-active mode of action. Further, bacteria did not develop resistance against these membrane-active polymers in sharp contrast to conventional antibiotics and lipopeptides, thus the polymers hold great promise to be used as coating materials for developing permanent antimicrobial paint.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rights?American Chemical Society, 2015en_US
dc.subjectNanoscience & Nanotechnologyen_US
dc.subjectMaterials Scienceen_US
dc.subjectmicrobicidal painten_US
dc.subjectantibacterial activityen_US
dc.subjectantifungal activityen_US
dc.subjectcontact-based noncovalent antimicrobial coatingen_US
dc.subjectbacterial resistanceen_US
dc.subjectwater-insoluble and organo soluble polymersen_US
dc.subjectmembrane-activated mode of actionen_US
dc.subjectAntimicrobial Coatingsen_US
dc.subjectAlkylated Polyethylenimineen_US
dc.titleBroad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure-Activity Relationship, and Membrane-Active Mode of Actionen_US
Appears in Collections:Research Papers (Kaustuv Sanyal)

Files in This Item:
File Description SizeFormat 
147.pdf6.98 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.