Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/1995
Title: Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure-Activity Relationship, and Membrane-Active Mode of Action
Authors: Hoque, Jiaul
Akkapeddi, Padma
Yadav, Vikas
Manjunath, Goutham B.
Uppu, Divakara S. S. M.
Konai, Mohini M.
Yarlagadda, Venkateswarlu
Sanyal, Kaustuv
Haldar, Jayanta
Keywords: Nanoscience & Nanotechnology
Materials Science
microbicidal paint
antibacterial activity
antifungal activity
contact-based noncovalent antimicrobial coating
bacterial resistance
water-insoluble and organo soluble polymers
membrane-activated mode of action
Antimicrobial Coatings
Candida-Albicans
Alkylated Polyethylenimine
Staphylococcus-Aureus
Infectious-Disease
Resistance
Bacterial
Mechanism
Biofilms
Dendrimers
Issue Date: 2015
Publisher: American Chemical Society
Citation: ACS Applied Materials & Interfaces
7
3
Hoque, J.; Akkapeddi, P.; Yadav, V.; Manjunath, G. B.; Uppu, D.; Konai, M. M.; Yarlagadda, V.; Sanyal, K.; Haldar, J., Broad Spectrum Antibacterial and Antifungal Polymeric Paint Materials: Synthesis, Structure-Activity Relationship, and Membrane-Active Mode of Action. ACS Applied Materials & Interfaces 2015, 7 (3), 1804-1815.
Abstract: Microbial attachment and subsequent colonization onto surfaces lead to the spread of deadly community-acquired and hospital-acquired (nosocomial) infections. Noncovalent immobilization of water insoluble and organo-soluble cationic polymers onto a surface is a facile approach to prevent microbial contamination. In the present study, we described the synthesis of water insoluble and organo-soluble polymeric materials and demonstrated their structure-activity relationship against various human pathogenic bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and beta lactam-resistant Klebsiella pneumoniae as well as pathogenic fungi such as Candida spp. and Cryptococcus spp. The polymer coated surfaces completely inactivated both bacteria and fungi upon contact (5 log reduction with respect to control). Linear polymers were more active and found to have a higher killing rate than the branched polymers. The polymer coated surfaces also exhibited significant activity in various complex mammalian fluids such as serum, plasma, and blood and showed negligible hemolysis at an amount much higher than minimum inhibitory amounts (MIAs). These polymers were found to have excellent compatibility with other medically relevant polymers (polylactic acid, PLA) and commercial paint. The cationic hydrophobic polymer coatings disrupted the lipid membrane of both bacteria and fungi and thus showed a membrane-active mode of action. Further, bacteria did not develop resistance against these membrane-active polymers in sharp contrast to conventional antibiotics and lipopeptides, thus the polymers hold great promise to be used as coating materials for developing permanent antimicrobial paint.
Description: Restricted access
URI: http://hdl.handle.net/10572/1995
ISSN: 1944-8244
Appears in Collections:Research Papers (Kaustuv Sanyal)

Files in This Item:
File Description SizeFormat 
147.pdf6.98 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.