Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/1992
Title: A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans
Authors: Varshney, Neha
Schaekel, Alida
Singha, Rima
Chakraborty, Tanmoy
van Wijlick, Lasse
Ernst, Joachim F.
Sanyal, Kaustuv
Keywords: Genetics & Heredity
kinase
Sch9
centromere
chromosome segregation
kinetochore
Yeast Saccharomyces-Cerevisiae
Kinetochore
Gene
Efficient
Transmission
Centromeres
Longevity
Chromatin
Homolog
MCM21
Issue Date: 2015
Publisher: Genetics Society of America
Citation: Genetics
199
3
Varshney, N.; Schaekel, A.; Singha, R.; Chakraborty, T.; van Wijlick, L.; Ernst, J. F.; Sanyal, K., A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans. Genetics 2015, 199 (3), 671-+.
Abstract: The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.
Description: Restricted access
URI: http://hdl.handle.net/10572/1992
ISSN: 0016-6731
Appears in Collections:Research Papers (Kaustuv Sanyal)

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