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dc.contributor.authorSutradhar, Sabyasachi
dc.contributor.authorYadav, Vikas
dc.contributor.authorSridhar, Shreyas
dc.contributor.authorSreekumar, Lakshmi
dc.contributor.authorBhattacharyya, Dibyendu
dc.contributor.authorGhosh, Santanu Kumar
dc.contributor.authorPaul, Raja
dc.contributor.authorSanyal, Kaustuv
dc.identifier.citationMolecular Biology of the Cellen_US
dc.identifier.citationSutradhar, S.; Yadav, V.; Sridhar, S.; Sreekumar, L.; Bhattacharyya, D.; Ghosh, S. K.; Paul, R.; Sanyal, K., A comprehensive model to predict mitotic division in budding yeasts. Molecular Biology of the Cell 2015, 26 (22), 3954-3965.en_US
dc.descriptionRestricted accessen_US
dc.description.abstractHigh-fidelity chromosome segregation during cell division depends on a series of concerted interdependent interactions. Using a systems biology approach, we built a robust minimal computational model to comprehend mitotic events in dividing budding yeasts of two major phyla: Ascomycota and Basidiomycota. This model accurately reproduces experimental observations related to spindle alignment, nuclear migration, and microtubule (MT) dynamics during cell division in these yeasts. The model converges to the conclusion that biased nucleation of cytoplasmic microtubules (cMTs) is essential for directional nuclear migration. Two distinct pathways, based on the population of cMTs and cortical dyneins, differentiate nuclear migration and spindle orientation in these two phyla. In addition, the model accurately predicts the contribution of specific classes of MTs in chromosome segregation. Thus we present a model that offers a wider applicability to simulate the effects of perturbation of an event on the concerted process of the mitotic cell division.en_US
dc.publisherAmerican Society for Cell Biologyen_US
dc.rights?American Society for Cell Biology, 2015en_US
dc.subjectCell Biologyen_US
dc.subjectSpindle Pole Bodyen_US
dc.subjectAsymmetric Cell-Divisionen_US
dc.subjectMicrotubule Captureen_US
dc.subjectFission Yeasten_US
dc.subjectKinetochore Captureen_US
dc.subjectPosition Checkpointen_US
dc.subjectDynamic Instabilityen_US
dc.subjectNuclear Migrationen_US
dc.titleA comprehensive model to predict mitotic division in budding yeastsen_US
Appears in Collections:Research Papers (Kaustuv Sanyal)

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