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Title: A comprehensive model to predict mitotic division in budding yeasts
Authors: Sutradhar, Sabyasachi
Yadav, Vikas
Sridhar, Shreyas
Sreekumar, Lakshmi
Bhattacharyya, Dibyendu
Ghosh, Santanu Kumar
Paul, Raja
Sanyal, Kaustuv
Keywords: Cell Biology
Spindle Pole Body
Asymmetric Cell-Division
Microtubule Capture
Fission Yeast
Kinetochore Capture
Position Checkpoint
Dynamic Instability
Nuclear Migration
Issue Date: 2015
Publisher: American Society for Cell Biology
Citation: Molecular Biology of the Cell
Sutradhar, S.; Yadav, V.; Sridhar, S.; Sreekumar, L.; Bhattacharyya, D.; Ghosh, S. K.; Paul, R.; Sanyal, K., A comprehensive model to predict mitotic division in budding yeasts. Molecular Biology of the Cell 2015, 26 (22), 3954-3965.
Abstract: High-fidelity chromosome segregation during cell division depends on a series of concerted interdependent interactions. Using a systems biology approach, we built a robust minimal computational model to comprehend mitotic events in dividing budding yeasts of two major phyla: Ascomycota and Basidiomycota. This model accurately reproduces experimental observations related to spindle alignment, nuclear migration, and microtubule (MT) dynamics during cell division in these yeasts. The model converges to the conclusion that biased nucleation of cytoplasmic microtubules (cMTs) is essential for directional nuclear migration. Two distinct pathways, based on the population of cMTs and cortical dyneins, differentiate nuclear migration and spindle orientation in these two phyla. In addition, the model accurately predicts the contribution of specific classes of MTs in chromosome segregation. Thus we present a model that offers a wider applicability to simulate the effects of perturbation of an event on the concerted process of the mitotic cell division.
Description: Restricted access
ISSN: 1059-1524
Appears in Collections:Research Papers (Kaustuv Sanyal)

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