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Title: Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain
Authors: Chaturbedy, Piyush
Kumar, Manoj
Salikolimi, Krishnachary
Das, Sadhan
Sinha, Sarmistha Halder
Chatterjee, Snehajyoti
Suma, B. S.
Kundu, Tapas Kumar
Eswaramoorthy, M.
Keywords: Chemistry
Pharmacology & Pharmacy
Compartmentalized drug delivery
Brain targeting
Physicochemical property
Iron-Oxide Nanoparticles
Nuclear Drug-Delivery
Carbon Nanospheres
Magnetic Nanoparticles
Theranostic Applications
Gold Nanoparticles
Cellular Uptake
Gene Delivery
Issue Date: 2015
Publisher: Elsevier Science Bv
Citation: Journal of Controlled Release
Chaturbedy, P.; Kumar, M.; Salikolimi, K.; Das, S.; Sinha, S. H.; Chatterjee, S.; Suma, B. S.; Kundu, T. K.; Eswaramoorthy, M., Shape-directed compartmentalized delivery of a nanoparticle-conjugated small-molecule activator of an epigenetic enzyme in the brain. J. Controlled Release 2015, 217, 151-159.
Abstract: Targeted drug delivery to specific subcellular compartments of brain cells is challenging despite their importance in the treatment of several brain-related diseases. Herein, we report on shape-directed intracellular compartmentalization of nanoparticles in brain cells and their ability to deliver therapeutic molecules to specific organelles. Iron oxide (Fe3O4) nanoparticles with different morphologies (spheres, spindles, biconcaves, and nanotubes) were synthesized and coated with a fluorescent carbon layer derived from glucose (Fe3O4@C). In vivo studies showed that the Fe3O4@C nanoparticles with biconcave geometry localized predominantly in the nuclei of the brain cells, whereas those with nanotube geometry were contained mostly in the cytoplasm. Remarkably, a small-molecule activator of histone acetyltransferases delivered into the nuclei of the brain cells using nanoparticles with biconcave geometry showed enhancement in enzymatic activity by a factor of three and resulted in specific gene expression (transcription) compared with that of the molecule delivered to the cytoplasm using nanotube geometry. (c) 2015 Elsevier B.V. All rights reserved.
Description: Restricted access
ISSN: 0168-3659
Appears in Collections:Research Papers (Tapas K. Kundu)

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