Please use this identifier to cite or link to this item: http://lib.jncasr.ac.in:8080/jspui/handle/10572/1878
Title: Revealing the trehalose mediated inhibition of protein aggregation through lysozyme-silver nanoparticle interaction
Authors: Siddhanta, Soumik
Barman, Ishan
Narayana, Chandrabhas
Keywords: Physical Chemistry
Materials Science
Physics
Polymer Science
Surface-Enhanced Raman
Circular-Dichroism Spectra
Bovine Serum-Albumin
Secondary Structure
Gold Nanoparticles
Conformational-Changes
Spectroscopy
Adsorption
Scattering
Stabilization
Issue Date: 2015
Publisher: Royal Society of Chemistry
Citation: Soft Matter
11
37
Siddhanta, S.; Barman, I.; Narayana, C., Revealing the trehalose mediated inhibition of protein aggregation through lysozyme-silver nanoparticle interaction. Soft Matter 2015, 11 (37), 7241-7249.
Abstract: We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein-nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.
Description: Restricted access
URI: http://hdl.handle.net/10572/1878
ISSN: 1744-683X
Appears in Collections:Research Articles (Chandrabhas N.)

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